Then there's the question of how safe papaya is for people other than those listed above, and whether it has any side effects. "Proteolytic enzymes have an excellent safety record, with no significant side effects reported," notes Hefferon. But, as with anything, he advises that their use be discontinued in the event that an allergic reaction ensues. (15)
Finally, how should papaya leaves be brewed and how often should it be consumed? According to the organization ECHO, in countries where it is used as a malaria preventive it is recommended that it be taken regularly on a twice-a-week schedule, as follows: "Use one fresh leaf which you boil in 2 liters of water. Let it boil a short time and let it rest for some minutes. Drink 1/4 of a cup each time. It is bitter, but it is not poisonous. You should not eat the raw leaves, however."